The article presents the results of the study of biochemical parameters of blood of cattle, contained in the industrial dairy complex and the effect of productivity on immunodeficiency states of cows. The authors have proved that in such animals acidification of the rumen occurs, which leads to the development of metabolic acidosis and pathological processes in the organism of cows. As a result of such disorders, there are hepatoses, hypo-microelementoses, ketoses and immunodeficiency states. Metabolic disorders can lead to the development of metabolic immunosuppression. When analyzing biochemical parameters in high-yielding cows, the cholesterol level was normal in 75% of sterile cows, calcium only in 12.5%, urea in 50% of the animals studied. The reserve alkalinity in all the animals of the deadwood group, the pregnant and newborns was below normal. The level of gamma globulins was within the limits of the norms from 40% to 66.7% of cows. The remaining animals showed an immunodeficiency state. Against the backdrop of such profound disturbances in metabolic processes, there is a constant risk of such contagious diseases as nodular dermatitis and foot and mouth disease. Significantly harder leukemia and other diseases. The authors proposed a set of measures aimed at increasing the level of biological safety in dairy complexes, where significant metabolic disorders are registered in animals.